RESISTENSI Salmonella sp. ISOLAT ASAL AYAM BROILER TERHADAP ANTIBIOTIK ABSTRAK Resistensi antibiotik sudah menjadi masalah global, hal ini terjadi kerena strain bakteri dalam tubuh sudah resisten terhadap antibiotik akibat penggunaan yang kurang tepat. Tujuan dari penelitian ini untuk mengetahui resistensi Salmonella sp. isolat asal ayam broiler terhadap antibiotik. Metode yang digunakan untuk penelitian ini yaitu metode difusi cakram Kirby Bauer. Sampel penelitian adalah 8 isolat asal ayam broiler koleksi Laboratorium Mikrobiologi Fakultas Kedokteran Hewan, Universitas Syiah Kuala. Penelitian ini menggunakan antibiotik amoksilin, streptomisin, kloramfenikol, siprofloksasin, gentamisin dan tetrasiklin. Data diolah secara deskriptif. Hasil penelitian didapatkan 5 isolat (62,5%) menunjukkan multidrug resistance dan tingkat resistensi terhadap antibiotik sangat tinggi dari 8 sampel yang diuji yaitu tetrasiklin 87,5 %(7/8), kloramfenikol 75% (6/8), amoksilin 62,5% (5/8) dan streptomisin 62,5% (5/8). Antibiotik yang masih sensitif yaitu gentamisin 62,5% (5/8) dan siprofloksasin 50% (4/8). Oleh sebab itu dapat disimpulkan bahwa Salmonella sp. telah resisten terhadap berbagai jenis antibiotik. Kata kunci: Salmonella sp., ayam broiler, resistensi antibiotik Salmonella sp. Resistance Broiler Chiken Isolates Against Antibiotics ABSTRACT Antibiotic resistance has become a global problem, this occurs because the strains of bacteria in the body are already resistant due to inappropriate use. This study aims to determine Salmonella sp.Resistance broiler chiken isolates against antibiotics. The method use for this research is the Kirby Bauer disc diffusion. The research Sample was 8 isolates from broiler chickens collected by the Laboratory of Microbiology, Faculty of Veterinary Medicine, Syiah Kuala University. This study used the antibiotic of amoxicilin, streptomycin, chloramphenicol, ciprofloxasin, gentamycin, and tetracyclin. The data were Processed descriptively. The result obtained that 5 isolates (62,5%) showed multidrug resistance and very high levels of resistance against antibiotics from 8 samples tested, namely tetracycline 87.5% (7/8), chloramphenicol 75% (6/8), amoxicillin 62.5% (5/8) and streptomycin 62.5% (5/8). Antibiotics that are still sensitive are gentamicin 62.5% (5/8) and ciprofloxasin 50% (4/8). Therefore it can be concluded that Salmonella sp. has been resistant to various types of antibiotics. Keywords: Salmonella sp., broiler chicken , antibiotic resistance