Plumbum poisoning has become a public health problem in the world. Vitamin E is an antioxidant compound that allergedly reduces cytotoxity plumbum. The purpose of this study was to determine the effect of vitamin E in mice exposed plumbum. This study is a laboratory experimental research which used a complete random design. In this study, vitamin E was given orally everyday for 7 days. Then plumbum was given intraperitoneally two hours after vitamin E. Examination of urea and creatinine was done 2 days after. There were 5 groups in this research, such as: Group I (aquadest), Group II (20 mg /KgBW plumbum), Group III (200 mg / KgBW Vitamin E + 20 mg / kgBW Plumbum), Group IV (500 mg / KgBW vitamin E + 20 mg / KgBW plumbum), Group V (1000 mg / KgBW vitamin E + 20 mg / KgBW plumbum). The results of this study indicated that there is no significant effect of vitamin E protection against Plumbum. This may be caused by a lack of high doses of vitamin E that was given so that the protection that caused was less effective. The conclusion of this study is vitamin E does not provide effective protection against plumbum exposure. Keywords : Plumbum, Vitamin E, Urea and creatine