GAMBARAN HISTOPATOLOGI OTOT FEMUR KELINCI (Lepus sp.) SETELAH IMPLAN PLAT LOGAM ABSTRAK Penelitian ini bertujuan untuk mengetahui perbedaan gambaran histopatologi otot femur kelinci (Lepus sp.) setelah implan plat besi dan tantalum. Kelompok perlakuan 1 (K1) kelinci yang diimplantasi menggunakan plat tantalum dan kelompok perlakuan 2 (K2) kelinci yang diimplantasi menggunakan plat besi di antara Musculus Vastus Lateralis dan tulang femur selama 2 bulan. Perubahan histologi yang diamati adalah ada tidaknya nekrosis, fibrosis dan tissue cavities pada jaringan otot femur kelinci. Hasil pengamatan secara mikroskpois ditemukan fibrosis, tetapi tidak ditemukan nekrosis dan tissue cavities. Terdapat perbedaan gambaran histopatologi otot kelinci (Lepus sp.) setelah penggunaan implan plat tantalum dan plat besi. Kata kunci : Kelinci, Tantalum, Besi, Histopatologi, Otot, Fibrosis, Nekrosis, Tissue Cavities. HISTOPATHOLOG OF RABBIT’S (Lepus sp.)FEMUR MUSCLE AFTER METAL PLATE IMPLANTATION ABSTRACT The aim of this study was to determine the differences in the histopathology of the rabbit femur (Lepus sp.) Muscle after iron plate and tantalum implants. The first treatment group (K1) rabbits implanted using tantalum plates and treatment group 2 (K2) rabbits were implanted using an iron plate between the Musculus Vastus Lateralis and the femur bone for 2 months. The histological changes observed were the presence or absence of necrosis, fibrosis and tissue cavities in the muscle tissue of the rabbit femur. The results of the study showed that fibrosis was found, but necrosis and tissue cavities were not found. There are differences in the histopatological muscle of rabbit (Lepus sp.) after the use of tantalum plate and iron plate implants. Keywords: Rabbit, Tantalum, Iron, Histopathology, Muscle, Fibrosis, Nekrotic, Tissue Cavities.