ABSTRAK Outcome fungsional pada pasien stroke merupakan defisit neurologis yang nyata dan dipengaruhi oleh lokasi dan luasi lesi pada area otak yang terkena infark. Penelitian ini bertuuan untuk mengetahui hubungan antara lokasi dan luas lesi berdasarkan hasil computed tomography dengan skor NIHSS pada pasien stroke iskemik akut di RSUDZA. Penelitian dilakukan di ruang rawat inap Mina 1 dan Mina 2 RSUDZA pada bulan Desember 2018 terhadap 70 responden dengan desain cross sectional. Metode sampling menggunakan non probability sampling dengan teknik quota sampling. Penelitian menggunakan instrumen NIHSS untuk mengukur derajat outcome fungsional dan hasil CT scan untuk menentukan lokasi dan luas lesi. Data diolah dan dianalisis menggunakan uji Kruskal-Wallis pada aplikasi SPSS. Hasil analisis menunjukkan mayoritas pasien mengalami skor NIHSS derajat sedang yaitu sebanyak 51 pasien (72,9%). Sebanyak 26 pasien (37,1%) mengalami lesi stroke di korteks, sedangkan 43 pasien (61,4%). Hasil uji Kruskal-Wallis antara lokasi lesi dan skor NIHSS menunjukkan p value 0,030. Uji terhadap hubungan luas lesi dan skor NIHHS menunjukkan p value 0,032. Hasil penelitian menunjukkan bahwa terdapat hubungan yang signifikan antara lokasi dan luas lesi berdasarkan hasil computed tomography dengan skor NIHSS pada pasien stroke iskemik akut di RSUDZA. Kata Kunci: Computed tomography, lokasi lesi, luas lesi, skor NIHSS, stroke iskemik akut ABSTRACT Functional outcome in stroke patients is a real neurologic deficits and influenced by location and lesion size in infarcted area of the brain. This study aims to determine the association between lesion location and size based on computed tomography and NIHSS score in acute ischemic stroke patients in RSUDZA. The study was conducted in patient room care Mina 1 and Mina 2 of RSUDZA on December 2018 with 70 respondents and using cross sectional design. Sampling method used was non probability sampling with quota sampling technique. Instruments used in this study were NIHSS to determine functional outcome degree and CT scan results to determine lesion location and size. The data were processed and analyzed with Kruskal-Wallis test with SPSS. Analysis results showed the majority of patients experienced moderate functional outcome, which were 51 patients (72,9%). A total of 26 patients (37,1%) had stroke lesion in cortex, while 43 patients (61,4%). Kruskal-Wallis test between lesion location and NIHSS score showed p value of 0,030. The test to determine association between lesion size and NIHSS score showed p value of 0,032. The result of this study was, there was a significant correlation between location and lesion size based on computed tomography and NIHSS score in acute ischemic stroke patients in RSUDZA Keywords: Computed tomography, lesion location, lesion size, NIHSS score, acute ischemic stroke