Kaki diabetik adalah infeksi, ulserasi maupun kerusakan jaringan ikat dalam yang berhubungan dengan neuropati dan penyakit pembuluh darah perifer pada tungkai bawah penderita DM. Kadar LDL Kolesterol yang tinggi dapat menyebabkan aterosklerosis sehingga terjadi iskemik pada kaki penderita DM. Penelitian ini bertujuan untuk mengetahui hubungan kadar LDL kolesterol terhadap kejadian kaki diabetik. Penelitian ini menggunakan metode analitik observasional dengan pendekatan cross sectional. Metode pengambilan sampel dengan accidental sampling padaperiode 14 November 2013- 14 Januari 2014 dengan jumlah sampel 42 orang. Analisis data menggunakan uji one way anova. Hasil penelitian menunjukkan 71,40% (30 orang) mempunyai kadar LDL kolesterol yang tinggi, 38,10% (16 orang) menderita kaki diabetik derajat 3, kadar rata-rata LDL kolesterol tertinggi terdapat pada derajat 0 yaitu 154,36 mg/dL, rata-rata kadar LDL kolesterol pada perempuan 135,23 mg/dL dan pada laki-laki 121,85 mg/dL. Hasil analisis menunjukkan bahwa tidak terdapat hubungan antara kadar LDL kolesterol terhadap kejadian kaki diabetik, dengan nilai p 0,40 (p>0,05). Kesimpulan: tidak terdapat hubungan LDL kolesterol terhadap kejadian kaki diabetik. Kata kunci: Kaki diabetik, LDL kolesterol, diabetes melitus ABSTRACK Diabetic foot is an infection, ulceration or destructionof the deep fibrous tissue associated with neuropathy and peripheral vascular disease on lower limb which is occur in diabetic patient. High level of LDL cholesterol can cause atherosclerosis and it cause ischemic foot of diabetic patient. The aim of this study is to find out the correlation between LDL cholesterol with incidence of diabetic foot. The type of this study is analytic observational with cross-sectional design. Method of the sampling was accidental sampling during the period of 14 November 2013 to 14 January 2014 with 42 respondents. The data was analyzed by One Way Anova. The result of this study showed that 71,40% (n=30) had high level of LDL cholesterol, majority of the patients 38,10% (n=16) were presented with Wagner grade 3, the average levels of LDL cholesterol highest at Wagner grade 0 was 154,36 mg/dL, the average levels of LDL cholesterol in women was 135,23 mg/dL and male 121,85 mg/dL. One Way Anova test showed that there was no correlation between LDL cholesterol with incidence of diabetic foot, with p value 0,40 (p>0.05). The conclusion of this study was no correlation between LDL cholesterol with incidence of diabetic foot. Keywords : Diabetic foot, LDL cholesterol, diabetes melitus