ABSTRAK Latar Belakang : Pada penderita PPOK terjadi penurunan fungsi paru yang dapat menyebabkan keterbatasan aktifitas sehingga terjadi penurunan kualitas hidup. Tujuan penelitian ini untuk menilai kualitas hidup pasien PPOK berdasarkan skala sesak, derajat PPOK dan frekuensi eksaserbasi. Metode : Design penelitian ini adalah deskriptif observasional dan subjek yang diteliti adalah 40 pasien PPOK stabil. Waktu penelitian selama 3 bulan mulai dari bulan Juli hingga September 2013 di Poliklinik paru RSUDZA Banda Aceh. Kualitas hidup dinilai menggunakan kuisioner SF-36, derajat sesak dinilai menggunakan skala sesak (mMRC Scale), derajat PPOK diukur menggunakan spirometri dan riwayat eksaserbasi diperoleh melalui wawancara. Hasil : Responden PPOK yang memiliki kualitas hidup buruk sebesar 70%, sesak napas derajat 3 dengan kualitas hidup buruk sebesar 60%, PPOK derajat 3 dengan kualitas hidup buruk sebesar 45% dan frekuensi eksaserbasi ≥ 2 kali/ tahun dengan kualitas hidup buruk sebesar 67,5%. Kesimpulan : 70% responden PPOK di Poliklnik Paru RSUDZA Banda Aceh mengalami kualitas hidup buruk, 60% responden sesak napas derajat 3 memiliki kualitas hidup buruk, 45% responden derajat 3 PPOK memilki kualitas hidup buruk dan 67,5% responden dengan frekuensi eksaserbasi ≥ 2 kali/ tahun memiliki kualitas hidup buruk. Kata Kunci: Penyakit Paru Obstruktif Kronik (PPOK), derajat PPOK, skala sesak (mMRC scale), eksaserbasi, kualitas hidup, kuisioner SF-36. ABSTRACT Background: In many COPD patients occur decline of lung function which caused activity limitations and consequently decreased the quality of life. The purpose of this research is to asses quality of life of COPD patients based on mMRC Scale, degree of COPD and exacerbation frequency. Methods: Design of this research is observational descriptive and subject under research is 40 patients with stable COPD. The period of this research is three months start from July 2013 until September 2013 held at Pulmonary Clinic of RSUDZA Banda Aceh. The quality of life was assessed using SF-36 quetionnaire, degree of dyspnoea was assessed using mMRC Scale, degree of COPD was assessed using spirometry, and exacerbation history was obtained through interviews. Result: COPD respondents who have poor quality of life is 70%, third-degree of dyspnoea with poor quality of life is 60%, third-degree of COPD with poor quality of life is 45% and exacerbation frequency (>2 times/year) with poor quality of life is 67,5% Conclusion:70% of COPD respondents at Pulmonary Clinic of RSUDZA Banda Aceh have poor quality of life, 60% % third-degree of dyspnoea respondents have poor quality of life, 45% third-degree of COPD respondents have poor quality of life and 67,5% exacerbation frequency (>2 times/year) respondents have poor quality of life. Keywords: COPD, degree of COPD , dyspnea Scale (mMRC Scale), exacerbation, quality of life, SF-36 quetionnaire.