ABSTRAK Kanker paru merupakan jenis penyakit keganasan yang menjadi penyebab utama kematian akibat keganasan pada laki-laki dan keempat pada perempuan, dengan Kanker Paru jenis Karsinoma Bukan Sel Kecil (KPKBSK) sebagai kasus terbanyak. Hubungan antara kanker paru dan gangguan kadar trombosit relatif sering terjadi pada pasien kanker paru stadium lanjut terutama pada Kanker Paru jenis Karsinoma Bukan Sel Kecil (KPKBSK). Trombositosis merupakan gangguan kadar trombosit yang lebih sering dijumpai dibanding trombositopenia pada penderita kanker paru khususnya Kanker Paru jenis Karsinoma Bukan Sel Kecil (KPKBSK). Tujuan Penelitian ini adalah untuk mengetahui hubungan antara Kanker Paru jenis Karsinoma Bukan Sel Kecil (KPKBSK) stadium lanjut terhadap gangguan kadar trombosit. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional teknik pengambilan sampel secara total sampling. Dari 33 responden didapatkan 54,5% kadar trombosit normal, 39,4% trombositosis dan 6,1% trombositopenia. Hasil uji korelasi Spearman menunjukan P value sebesar 0,6 (P>0,05) kesimpulan penelitian ini adalah tidak terdapat hubungan antara Kanker Paru jenis Karsinoma Bukan Sel Kecil (KPKBSK) stadium lanjut terhadap gangguan kadar trombosit di RSUDZA Banda Aceh. Kata kunci : Kanker Paru, Kadar Trombosit, Trombositosis, Trombositopenia. ABSTRACT Lung cancer is a type of malignant disease that is the leading cause of death from malignancy in males and females in women, with Non-Small Cell Lung Carcinoma (NSCLC) as the most cases. The relationship between lung cancer and abnormalities of thrombocyte rate is relatively common in patients with advanced lung cancer, especially in Non-Small Cell Lung Carcinoma (NSCLC). Thrombocytosis is an abnormalitiy of thrombocyte rate that more common than thrombocytopenia in patients with lung cancer, especially Non-Small Cell Lung Carcinoma (NSCLC). This study aims to determine the relationship between advanced stage Non-Small Cell Lung Carcinoma (NSCLC) with thrombocyte rate abnormalities. This research is an observational analytic research with cross sectional approach of total sampling technique. Out of 33 respondents obtained 54.5% normal thrombocyte rate, 39.4% thrombocytosis and 6.1% thrombocytopenia. The results of the bivariate analysis with Spearman Correlation test between advanced stage of NSCLC and thrombocyte rate showed P value of 0.6 (P> 0.05). Conclusion of this study is there is no relationship between advanced stage of NSCLC to thrombosis rate abnormalities in RSUDZA Banda Aceh. Keywords : Lung Cancer, Thrombocyte Rate ,Thrombocytosis,Thrombocytopenia.