ABSTRAC “Fitri Isnaini, Effect of Variety and Concentration of Liquid Organic Fertilizer IN Grow the Plant Growth and Yield of Lettuce (Lactuca sativa L.)” under the guidance of the mother nurhayati as main supervisor and Mr. Mahdi,AS. as a mentor members. This study aims to determine the effect of variety and concentration of liquid organic fertilizer DI Grow is right for improving growth and yield of lettuce, as well as to determine the interaction between the two factors. The experimental design used in this study is a randomized block design (RGD) 3 x 3 factorial with 3 replications, so there are 9 combined treatment and 27 units of the experiment, each experimental unit consisted of 4 samples. Factors studied were varieties (V) and concentration of liquid organic fertilizer IN Grow (K). Factors varieties (V) consists of: V1 = Grand Rapids, V2 = Karina, V3 = Fresh and Organic Liquid Fertilizer Concentration factor IN Grow (K) consisting of: K0 = 0ml/liter water (control) K1 = 2 ml / liter of water K2 = 4 ml / liter of water Matters was observed plant height, number of leaves, leaf length, leaf width, stem diameter, fresh weight per plant and crop yields wet weight per hectare. The results showed that varieties are very real effect on plant height and 30 HST age of 10.20, 10.20 and total leaf age 30 HST, age 10 HST leaf length, stem diameter HST ages 20 and 30, showed significant plant height and width Leaf age 20 HST, but no real effect on the length of the leaf ages of 20 and 30 HST, wide leaves the ages of 10 and 30 HST, cropyields irrigated wet weight and wet weight cropyields perhectare. Growth and yield the best lettuce varieties found in Karina. Concentration of liquid organic fertilizer D. I.Grow take effect highly significant plant height and leaf width HST age 20. Significant effect on plant height and stem diameter HST age 30, age 20 HST leaf length and fresh weight per plant cropyields wet. But the effect does not significantly affect plant height age 10 day , leaf number aged 10, 20 and 30 days after planting, leaf length and leaf width ages of 10 and 30 days after planting, stem diameter and age 20 HST cropyields weight per plant. Growth and yield of lettuce plants best observed in the treatment without the use of fertilizers or control. There is no real interaction between varieties with liquid organic fertilizer concentration D. I. Grow against all variables lettuce crop growth and yield were observed.