ABSTRAK Kentang (Solanum tuberosum) merupakan salah satu tanaman berkhasiat yang dapat mengatasi jerawat. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol kulit kentang terhadap bakteri penyebab jerawat Staphylococcus epidermidis dan Staphylococcus aureus, dan besarnya zona hambat yang dihasilkan. Ekstrak etanol kulit kentang diperoleh dengan menggunakan metode maserasi. Pengujian aktivitas antibakteri menggunakan metode Kirby Bauer dengan variasi konsentrasi ekstrak yaitu 5, 10, 15, 20, dan 25%, kontrol positif menggunakan klindamisin 2 µg, dan kontrol negatif pelarut etanol. Hasil uji fitokimia menunjukkan ekstrak etanol kulit kentang mengandung alkaloid, tanin, triterpenoid, dan saponin. Karakterisasi ekstrak etanol kulit kentang memperoleh hasil yaitu kadar air sebesar 7,53% ± 0,83; kadar abu total 4,76% ± 0,75; kadar sari larut air 50,33% ± 4,18; dan kadar sari larut etanol 34% ± 3,74. Hasil pengujian aktivitas antibakteri menunjukkan bahwa ekstrak etanol kulit kentang tidak dapat menghambat pertumbuhan bakteri Staphylococcus epidermidis dan Staphylococcus aureus. Kata kunci: Kulit kentang (Solanum tuberosum), Staphylococcus epidermidis, Staphylococcus aureus. ABSTRACT Potato (Solanum tuberosum) is one of plants that can solve the problem that linked with acne. The antibacterial activity test of ethanol extract from potato peels (Solanum tuberosum) against bacterial that causes acne such as Staphylococcus epidermidis and Staphylococcus aureus have been done. The potato peels ethanol extract was obtained by maceration method. The antibacterial activity test was performed using Kirby Bauer method with 5, 10, 15, 20, and 25% concentration of the potato peels ethanol extract. The results of phytochemical test showed that the potato peels ethanol extract contains alkaloid, tannin, triterpenoid, and saponin. The water content of potato peels ethanol extract was 7,53% ± 0,83 and the total ash content was 4,76% ± 0,75. Based on the water-soluble extractive value, it was known that the potato peels ethanol extract is 50,33% ± 4,18, differ with the ethanol-soluble extractive value, which is 34% ± 3,74. The results of antimicrobial activity test showed that the potato peels ethanol extract in this research had no inhibitory activity against Staphylococcus epidermidis and Staphylococcus aureus. Keywords: Potato peel (Solanum tuberosum), Staphylococcus epidermidis, Staphylococcus aureus.