Abstrak

Baca Juga : FORMULASI SEDIAAN LIP BALM DENGAN MINYAK ALMOND (PRUNUS AMYGDALUS DULCIS) SEBAGAI EMOLIEN DAN EKSTRAK ETANOL UMBI BIT (BETA VULGARIS L.) SEBAGAI PEWARNA (Zata Yumni Sudirman, 2020) ,

Baca Juga : INVENTARISASI DAN STUDI ETNOBOTANI TUMBUHAN GADUNG (DIOSCOREA SPP.) DI KABUPATEN ACEH UTARA (Hanny Herzegovina, 2015) ,

ng memenuhi persyaratan yaitu 2 menit 29 detik ± 12 detik dan kadar air isi kapusl yang baik yaitu kurang dari 10%. uji aktivitas antidiabetes dilakukan pada mencit (mus muscullus) dengan induktor diabetes berupa aloksan. mencit dibagi kedalam 7 kelompok, dimana kelompok 1 (kontrol negatif) diberikan cmc-na 0,5%, kelompok 2 (kontrol positif) diberikan tablet metformin. kelompok 3 diberikan ekstrak etanol umbi ubi kelapa ungu dengan dosis 1120 mg/kgbb manusia. kelompok 4,5,6 dan 7 diberikan sediaan kapsul dengan dosis 350 mg/kgbb manusia (1 kapsul), 700 mg/kgbb manusia (2 kapsul), 1050 mg/kgbb manusia (3 kapsul) dan 1400 mg/kgbb manusia (4 kapsul). persentase penurunan kadar gula darah pada hari ke-21 pemberian perlakuan yang diperoleh berturut-turut 11,9%, 30,30%, 24,85%, 17,86%, 20,14%, 22,9% dan 34,82% dengan pvalue (sig.) < ? (0.05). kata kunci: ekstrak etanol umbi ubi kelapa ungu, kapsul, antidiabetes, kadar gula darah abstract the ethanol extract of purple yam tuber (dioscorea alata l.) capsules as an antidiabetic has been conducted. ethanol extract of purple yam tubers was obtained using maceration method using 96% ethanol solvent. characterization results showed ethanol extract of purple yam tubers had a water content of 21.6% ± 0.29, total ash content of 9.21% ± 0.114, water soluble extract content of 44.16% ± 1.44 and ethanol soluble extract content of 67, 5% ± 2.5. phytochemical screening results showed that the ethanol extract of purple yam tubers contained alkaloid compounds, flavonoid, saponins, tannins and steroids. the composition of the capsules consisted of ethanol extract of 46.6% purple coconut sweet potato, 46.6% vivapur 101, 3% aerosil, 1% magnesium stearate and 2% talc. the results of the capsule mass evaluation meet the requirements of a standpoint of 16.12 ± 1.50, a flow rate of 7.13 g / s ± 0.88, a hauster's ratio and a carr's index of 1.2 and 6.32%. the results of the preparation of the preparations showed that the capsules had uniform weights, disintegration times that met the requirements of 2 minutes 29 seconds ± 12 seconds and the requirements of water content is less than 10%. antidiabetic activity test was carried out on mice (mus muscullus) with diabetes inductor in the form of alloxan. mice were divided into 7 groups, group 1 was negative control in the form of cmc-na 0.5%, group 2 was positive control in the form of metformin tablets. group 3 is in the form of ethanol extract of purple coconut tubers at a dose of 1200 mg / kg human. groups 4,5,6 and 7 are capsules at a dose of 350 mg / kg human (1 capsule), 700 mg / kg human (2 capsules), 1050 mg / kg human (3 capsules) and 1400 mg / kg human (4 capsule). the percentage decrease in blood sugar levels on the 21st day of treatment obtained were 11.9%, 30.30%, 24.85%, 17.86%, 20.14%, 22.9% and 34.82, respectively. % with p-value

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