Abstrak

Baca Juga : GAMBARAN MAKROSKOPIS HEPAR TIKUS (RATTUS NOVERGICUS) STRAIN WISTAR PADA UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN BINAHONG (ANREDERA CORDIFOLIA (TEN.) STEENIS) (Nissa Seurunie, 2019) ,

Baca Juga : EFIKASI EKSTRAK ETANOL DAUN BINAHONG (ANREDERA CORDIFOLIA (TEN) STEENIS) TERHADAP PENURUNAN KADAR GULA DARAH PADA TIKUS PUTIH (RATTUS NORVEGICUS) (Dini Raikhani Danial , 2015) ,

asi dosis. pada kelompok perlakuan 1 diberikan dosis 300 mg/kg.bb, kelompok perlakuan 2 diberikan dosis 600 mg/kg.bb, kelompok perlakuan 3 diberikan dosis 1200 mg/kg.bb, dan kelompok perlakuan 4 diberikan dosis 2400 mg/kg.bb. data hasil pengamatan makroskopis hepar yang didapatkan akan dianalisis dengan menggunakan uji kruskal wallis, sedangkan data pengamatan bobot hepar, dan berat badan hewan coba akan dianalisis dengan uji anova. hasil penelitian menunjukkan ekstrak etanol daun binahong pada seluruh kelompok perlakuan mempengaruhi berat badan hewan coba pada hari ke-1 setelah pemberian sediaan uji dan mempengaruhi makroskopis hepar tikus berupa perubahan warna hepar. pada kelompok perlakuan 2, 3, dan 4 ditemukan adanya peningkatan bobot hepar absolut dan bobot hepar relatif hewan coba. kata kunci: makroskopis hepar, binahong (anrendera cordifolia (ten.)steenis) abstract binahong (anrendera cordifolia (ten.) steenis) is a traditional medicinal plant commonly used by the community because of its various benefits such as: reduce uric acid levels, heal burns, open wounds, cuts and as an antibacterial. this acute toxicity test was aimed to determine the safety of ethanol extract of binahong leaves given orally and assess their effects on macroscopic liver, liver weight, and body weight of experimental animals. this research was an experimental study which used a complete randomized design with a post-test only method with control group design. the animals used in this study were wistar strain male rats (ratus novergicus) 25 rats were grouped into 5, each group was consisting of 5 rats. the experimental groups consisted of 1 control group given 1% cmc and 4 treatment groups given binahong leaf ethanol extract with diversified doses. the treatment group 1 was given a dose of 300 mg / kg.bb, group 2 was given a dose of 600 mg / kg.bb, group 3 was given a dose of 1200 mg / kg.bb, and group 4 was given a dose of 2400 mg / kg. the macroscopic observation of liver data was analyzed using the kruskal wallis test while observations of liver weight and body weight of experimental animals was analyzed by anova test. the results showed that ethanol extract of binahong leaves in all treatment groups affected the body weight of the animals on day one after the administration of the test and affected the rat macroscopic liver in the form of liver discoloration. the treatment groups 2, 3 and 4, there were an increase in absolute liver weight and relative liver weight of experimental animals. keywords: macroscopic liver, binahong (anrendera cordifolia (ten.)

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