Abstrak

Baca Juga : UJI AKTIVITAS ANTIJAMUR EKSTRAK N-HEKSANA, ETIL ASETAT, DAN METANOL DAUN SEMBUNG (BLUMEA BALSAMIFERA (L.) DC)TERHADAP PERTUMBUHAN JAMUR CANDIDA ALBICANS RESISTEN FLUKONAZOL (JUMARISWAN, 2017) ,

Baca Juga : UJI AKTIVITAS EKSTRAK ETIL ASETAT DAUN SINTRONG (CRASSOCEPHALUM CREPIDIOIDES (BENTH.) S. MOORE) TERHADAP PERTUMBUHAN JAMUR CANDIDA ALBICANS (RAHMAWATI, 2016) ,

okimia ekstrak n-heksana mengandung senyawa steroid, ekstrak etil asetat mengandung senyawa saponin dan steroid. sedangkan pada ekstrak metanol mengandung senyawa flavonoid, saponin, tanin, dan steroid. hasil karakterisasi kadar air ekstrak n-heksana sebesar 11,86%, ekstrak etil asetat sebesar 16,23%, dan ekstrak metanol sebesar 26,18%. hasil karakterisasi kadar abu ekatrak n-heksana 6,4%, ekstrak etil asetat 5,02%, dan ekstrak metanol 1,64%. hasil karakterisasi kadar sari larut air ekstrak n-heksana sebesar 26%, ekstrak etil asetat sebesar 49%, dan ekstrak metanol sebesar 74,6%. hasil karakterisasi kadar sari larut etanol ekstrak n-heksana sebesar 39%, ekstrak etil asetat sebesar 80%, dan ekstrak metanol sebesar 78,6%. pengujian aktivitas antijamur menunjukkan bahwa ekstrak n-heksana dan etil asetat tidak memiliki aktivitas sebagai antijamur. sedangkan hasil uji aktivitas terhadap ekstrak metanol kosentrasi 10, 20, 30, dan 40% mampu menghambat pertumbuhan candida albicans resisten flukonazol dengan daya hambat 5,6; 7,17; 8,25; dan 11,4 mm kata kunci: daun peria pantai (colubrina asiatica l. brong), candida albicans resisten flukonazol, dan maserasi bertingkat. abstract resistance of fungal to antifungals had lead researchers to find new alternative medicines from material nature. peria pantai (colubrina asiatica l. brong) is a plant that has been shown to have activity an antifungal. this reasearch aim is extract characterization and antifungal activity test of peria pantai leaf extracts. the fungus were subjected in this study was candida albicans resistant fluconazole. the extraction was done as solvent multistep using n-hexane, ethyl acetate, and methanol. characterization of extracts include moisture content, total ash value, water soluble extract and ethanol soluble extract. the antifungal activity test of peria pantai leaf extract against candida albicans resistant fluconazole was done by kirby-bauer method with the concentration of extract 10, 20, 30, and 40%. phytochemical test, characterization of extract, and antifungal activity test were performed on all three extracts. the result of phytochemical test of n-hexane extract contain steroid compound, ethyl acetate extract contain saponin and steroid compounds. while the methanol extract contain flavonoid, saponin, tannin, and steroid compound. the result of extract characterization were water content of n-hexane extract of 11,86%, ethyl acetate extract 16,23%, and methanol extract 26,18%. total ash value of n-hexane extract 6,4%, ethyl acetate extract 5,02%, and methanol extract 1,64%. water soluble extract content of n-hexane 26%, ethyl acetate extract 49%, and methanol extract 74,6%. the ethanol soluble extract content of n-hexane 39%, ethyl acetate extract 80%, and methanol extract 78,6%. testing of antifungal activity showed that n-hexane and ethyl acetate extracts had no activity as antifungal. while the result of activity test on methanol extract 10, 20, 30, and 40% concentration able to inhibit growth of candida albicans resistant fluconazole with inhibitory power 5,6; 7,17; 8,25; and 11,4 mm keywords: peria pantai leaves (colubrina asiatica l. brong), candida albicans resistant fluconazole, and graded

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