Abstrak

Baca Juga : UJI TOKSISITAS EKSTRAK ETANOL KAYU MANIS (CINNAMOMUM BURMANNII NESS EX BI.) TERHADAP GAMBARAN HISTOLOGI HATI DAN GINJAL TIKUS (RATTUS NOVERGICUS) (ratna sari, 2017) ,

Baca Juga : AKTIVITAS ANTIBAKTERI EKSTRAK KAYU MANIS (CINNAMOMUM BURMANNII) TERHADAP PERTUMBUHAN ENTEROCOCCUS FAECALIS (Cut Aisa Qamari, 2014) ,

analisis dengan anava. hasil penelitian menunjukkan bahwa pemberian ekstrak etanol kayu manis berpengaruh nyata terhadap degenerasi dan nekrosis pada sel hati dan sel tubulus ginjal. semakin meningkat dosis ekstrak etanol kayu manis yang diberikan maka semakin meningkat jumlah degenerasi dan nekrosis sel hati. peningkatan dosis mempengaruhi peningkatan jumlah sel tubulus ginjal yang mengalami nekrosis, tetapi tidak mempengaruhi degenerasi sel tubulus ginjal dan tidak menunjukkan perubahan yang berarti terhadap perubahan gejala klinis tikus perlakuan. kata kunci : cinnamomum burmannii ness ex bi., toksisitas, hati, ginjal, degenerasi dan nekrosis. abstract plants cinnamon (cinnamomum burmannii ness ex bi.) has been used by the people as a herbal medicine in treating various types of diseases. this research aims to observe the effect of cinnamic toxicity stem on structure of rat’s liver and kidney. the research was conducted experimentally using completely randomized design (ral) consisted of 4 treatments with 5 replications in each treatment. the treatment consisted of etanol extract of cinnamon stem at a dosage 0 mg/kg bw (control) 200 mg / kg bw (p1), 400 mg / kg bw (p2) and 800 mg / kg bw (p3). the cinnamon extract was given for 14 days, on the 15th day performed surgical carcasses for the removal of liver and kidney organs. the proportion of the number degenerated and necrosis liver cells and renal tubular cells was analyzed by analysis of variance (anava) and continued by duncan multiple-range test. examination of clinical symptoms was analyzed descriptively, except the relative weight of the organ and the size of the color change was analyzed by anava. the results showed that administration of cinnamon ethanol extract significantly affected the degeneration and necrosis of liver cells and renal tubular cells. increasing the doses (cinnamon ethanol extract) given, the more increasing the number of degenerated liver cells and necrosis. increased doses affect the increase in the number of renal tubular cells undergoing necrosis, but do not affect the degeneration of renal tubular cells and did not show any significant change in the clinical symptoms of rats treated. key words : cinnamomum burmannii ness ex bi., toxicity, liver, kidney, degeneration and

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